Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

A new atlas pairs DNA methylation with 3D genome folding in 86,689 human cells and ties disease risk to specific cell types.

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Precise activation of tens of thousands of genes is critical for healthy development and growth. Specialized segments of our DNA are responsible for carefully orchestrating genetic sequences that ...

A molecular illustration of the crowded interior and cell envelope of Escherichia coli. (David S. Goodsell, The Scripps ...

A new study by researchers at the Perelman School of Medicine at the University of Pennsylvania reveals that the ...

Researchers have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends signals through an unusual ...

A major new discovery could inspire improved treatments for cancer and genetic diseases. Coiled within our cells are fragile threads of DNA that contain the codes of life— determining when each of our ...

The left-handed spiral of each Z-DNA strand is highlighted on the left. Binding and bonding of the two zinc finger domains (shown in red) from the CTCF protein to Z-DNA (shown in blue). This protein ...

Researchers filmed the enzyme APE1 hunting DNA damage one molecule at a time. Its shapeless tail turned out to do the finding ...